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Sciatica: What It Is, How Common It Is, and What Actually Helps... Sciatica  is a term used to describe pain caused by irritation or compression of the sciatic nerve—the largest nerve in the body. Rather than being a diagnosis itself, sciatica is a set of symptoms  that usually include pain, tingling, numbness, or weakness that travels from the lower back or buttock down the leg. What causes sciatica? Sciatica most commonly occurs when structures in the lower spine place pres